ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Glycosyl hydrolase family 13 catalytic domain-containing protein

Intermolecular
Cysteine 144 of Solute carrier family 7 member 9 and cysteine 114
Intramolecular
Cysteine 673 and cysteine 685
Cysteine 242 and cysteine 273
Cysteine 571 and cysteine 666
A redox-regulated disulphide may form between cysteine 144 of Solute carrier family 7 member 9 and cysteine 114 of Glycosyl hydrolase family 13 catalytic domain-containing protein.

Details

Redox score ?
82
PDB code
7nf6
Structure name
ovine b0,+at-rbat heterodimer
Structure deposition date
2021-02-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide A name
Solute carrier family 7 member 9
Peptide B name
Glycosyl hydrolase family 13 catalytic domain-containing protein
Peptide A accession
A0A6P3EL78
Peptide B accession
A0A6P7DVK7
Peptide A residue number
144
Peptide B residue number
114

Ligandability

Cysteine 144 of Solute carrier family 7 member 9

Cysteine 114 of Glycosyl hydrolase family 13 catalytic domain-containing protein

A redox-regulated disulphide may form within Glycosyl hydrolase family 13 catalytic domain-containing protein between cysteines 673 and 685.

Details

Redox score ?
87
PDB code
7nf7
Structure name
ovine rbat ectodomain homodimer, asymmetric unit
Structure deposition date
2021-02-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A6P7DVK7
Residue number A
673
Residue number B
685
Peptide name
Glycosyl hydrolase family 13 catalytic domain-containing protein

Ligandability

Cysteine 673 of Glycosyl hydrolase family 13 catalytic domain-containing protein

Cysteine 685 of Glycosyl hydrolase family 13 catalytic domain-containing protein

A redox-regulated disulphide may form within Glycosyl hydrolase family 13 catalytic domain-containing protein between cysteines 242 and 273.

Details

Redox score ?
86
PDB code
7nf7
Structure name
ovine rbat ectodomain homodimer, asymmetric unit
Structure deposition date
2021-02-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A6P7DVK7
Residue number A
242
Residue number B
273
Peptide name
Glycosyl hydrolase family 13 catalytic domain-containing protein

Ligandability

Cysteine 242 of Glycosyl hydrolase family 13 catalytic domain-containing protein

Cysteine 273 of Glycosyl hydrolase family 13 catalytic domain-containing protein

A redox-regulated disulphide may form within Glycosyl hydrolase family 13 catalytic domain-containing protein between cysteines 571 and 666.

Details

Redox score ?
82
PDB code
7nf8
Structure name
ovine (b0,+at-rbat)2 hetero-tetramer, asymmetric unit, rigid-body fitted
Structure deposition date
2021-02-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0A6P7DVK7
Residue number A
571
Residue number B
666
Peptide name
Glycosyl hydrolase family 13 catalytic domain-containing protein

Ligandability

Cysteine 571 of Glycosyl hydrolase family 13 catalytic domain-containing protein

Cysteine 666 of Glycosyl hydrolase family 13 catalytic domain-containing protein

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