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NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Intramolecular
Cysteine 86 and cysteine 97
Cysteine 100 and cysteine 114
Cysteine 86 and cysteine 114
Cysteine 201 and cysteine 248
Cysteine 86 and cysteine 100
Cysteine 86 and cysteine 201
Cysteine 198 and cysteine 248
Cysteine 97 and cysteine 100
Cysteine 204 and cysteine 248
Cysteine 153 and cysteine 159
More...
Cysteine 150 and cysteine 153
Cysteine 198 and cysteine 201
Cysteine 201 and cysteine 204
Cysteine 159 and cysteine 248
Cysteine 198 and cysteine 204
Cysteine 150 and cysteine 159
Cysteine 153 and cysteine 248
Cysteine 97 and cysteine 201
Cysteine 75 and cysteine 100
Cysteine 97 and cysteine 114
A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 86 and 97 (64 and 75 respectively in this structure).

Details

Redox score ?
76
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
5
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
86
Residue number B
97
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 86 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 97 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 100 and 114 (78 and 92 respectively in this structure).

Details

Redox score ?
70
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
4
Half-sphere exposure sum ?
85
Minimum pKa ?
8
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
100
Residue number B
114
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 100 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 86 and 114 (64 and 92 respectively in this structure).

Details

Redox score ?
68
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
5
Half-sphere exposure sum ?
85
Minimum pKa ?
5
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
86
Residue number B
114
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 86 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 201 and 248 (179 and 226 respectively in this structure).

Details

Redox score ?
60
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
78
Minimum pKa ?
7
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
201
Residue number B
248
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 201 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 86 and 100 (64 and 78 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
84
Minimum pKa ?
5
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
86
Residue number B
100
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 86 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 86 and 201 (64 and 179 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
5
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
86
Residue number B
201
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 86 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 198 and 248 (176 and 226 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
7
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
198
Residue number B
248
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 198 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 97 and 100 (75 and 78 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
56
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
85
Minimum pKa ?
8
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
97
Residue number B
100
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 97 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 204 and 248 (182 and 226 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
7
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
204
Residue number B
248
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 204 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 153 and 159 (131 and 137 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
82
Minimum pKa ?
9
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
153
Residue number B
159
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 153 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 150 and 153 (128 and 131 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
9
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
150
Residue number B
153
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 150 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 153 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 198 and 201 (176 and 179 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
198
Residue number B
201
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 198 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 201 and 204 (179 and 182 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
6
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
201
Residue number B
204
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 201 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 159 and 248 (137 and 226 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
7
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
159
Residue number B
248
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 159 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 198 and 204 (176 and 182 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
12
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
198
Residue number B
204
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 198 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 150 and 159 (128 and 137 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
87
Minimum pKa ?
13
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
150
Residue number B
159
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 150 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 159 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 153 and 248 (131 and 226 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
7
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
153
Residue number B
248
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 153 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 97 and 201 (75 and 179 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
97
Residue number B
201
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 97 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 75 and 100 (53 and 78 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
8
% buried
99
Peptide accession
A0A8D1AAL8
Residue number A
75
Residue number B
100
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 75 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial between cysteines 97 and 114 (75 and 92 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
7vxu
Structure name
matrix arm of deactive state ci from q10 dataset
Structure deposition date
2021-11-13
Thiol separation (Å)
7
Half-sphere exposure sum ?
86
Minimum pKa ?
17
% buried
100
Peptide accession
A0A8D1AAL8
Residue number A
97
Residue number B
114
Peptide name
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Ligandability

Cysteine 97 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 114 of NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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