Ubiquitin-like modifier-activating enzyme 6
Intramolecular
Cysteine 468 and cysteine 473
Cysteine 347 and cysteine 433 L
Cysteine 311 and cysteine 414
Cysteine 699 and cysteine 770
Cysteine 449 and cysteine 455
Cysteine 156 and cysteine 174
Cysteine 197 and cysteine 414
Cysteine 156 and cysteine 197
7pvn B 468 B 473
A redox-regulated disulphide may form within Ubiquitin-like modifier-activating enzyme 6 between cysteines 468 and 473.
Details
Redox score ?
63
PDB code
7pvn
Structure name
crystal structure of human uba6 in complex with atp
Structure deposition date
2021-10-05
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
100
Peptide accession
A0AVT1
Residue number A
468
Residue number B
473
Peptide name
Ubiquitin-like modifier-activating enzyme 6
Ligandability
Cysteine 468 of Ubiquitin-like modifier-activating enzyme 6
Cysteine 473 of Ubiquitin-like modifier-activating enzyme 6
7sol A 347 A 433
A redox-regulated disulphide may form within Ubiquitin-like modifier-activating enzyme 6 between cysteines 347 and 433. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
7sol
Structure name
crystal structures of the bispecific ubiquitin/fat10 activating enzyme, uba6
Structure deposition date
2021-10-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
4
Peptide accession
A0AVT1
Residue number A
347
Residue number B
433
Peptide name
Ubiquitin-like modifier-activating enzyme 6
Ligandability
Cysteine 347 of Ubiquitin-like modifier-activating enzyme 6
Cysteine 433 of Ubiquitin-like modifier-activating enzyme 6
7pyv A 311 A 414
A redox-regulated disulphide may form within Ubiquitin-like modifier-activating enzyme 6 between cysteines 311 and 414. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7pyv
Structure name
crystal structure of human uba6 in complex with the ubiquitin-like modifier fat10
Structure deposition date
2021-10-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
72
Peptide accession
A0AVT1
Residue number A
311
Residue number B
414
Peptide name
Ubiquitin-like modifier-activating enzyme 6
Ligandability
Cysteine 311 of Ubiquitin-like modifier-activating enzyme 6
Cysteine 414 of Ubiquitin-like modifier-activating enzyme 6
7sol A 699 A 770
A redox-regulated disulphide may form within Ubiquitin-like modifier-activating enzyme 6 between cysteines 699 and 770. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
7sol
Structure name
crystal structures of the bispecific ubiquitin/fat10 activating enzyme, uba6
Structure deposition date
2021-10-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
9
% buried
44
Peptide accession
A0AVT1
Residue number A
699
Residue number B
770
Peptide name
Ubiquitin-like modifier-activating enzyme 6
Ligandability
Cysteine 699 of Ubiquitin-like modifier-activating enzyme 6
Cysteine 770 of Ubiquitin-like modifier-activating enzyme 6
7sol A 449 A 455
A redox-regulated disulphide may form within Ubiquitin-like modifier-activating enzyme 6 between cysteines 449 and 455. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7sol
Structure name
crystal structures of the bispecific ubiquitin/fat10 activating enzyme, uba6
Structure deposition date
2021-10-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
81
Minimum pKa ?
12
% buried
96
Peptide accession
A0AVT1
Residue number A
449
Residue number B
455
Peptide name
Ubiquitin-like modifier-activating enzyme 6
Ligandability
Cysteine 449 of Ubiquitin-like modifier-activating enzyme 6
Cysteine 455 of Ubiquitin-like modifier-activating enzyme 6
7sol C 156 C 174
A redox-regulated disulphide may form within Ubiquitin-like modifier-activating enzyme 6 between cysteines 156 and 174. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7sol
Structure name
crystal structures of the bispecific ubiquitin/fat10 activating enzyme, uba6
Structure deposition date
2021-10-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
98
Peptide accession
A0AVT1
Residue number A
156
Residue number B
174
Peptide name
Ubiquitin-like modifier-activating enzyme 6
Ligandability
Cysteine 156 of Ubiquitin-like modifier-activating enzyme 6
Cysteine 174 of Ubiquitin-like modifier-activating enzyme 6
7sol A 197 A 414
A redox-regulated disulphide may form within Ubiquitin-like modifier-activating enzyme 6 between cysteines 197 and 414. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
7sol
Structure name
crystal structures of the bispecific ubiquitin/fat10 activating enzyme, uba6
Structure deposition date
2021-10-31
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
83
Peptide accession
A0AVT1
Residue number A
197
Residue number B
414
Peptide name
Ubiquitin-like modifier-activating enzyme 6
Ligandability
Cysteine 197 of Ubiquitin-like modifier-activating enzyme 6
Cysteine 414 of Ubiquitin-like modifier-activating enzyme 6
7pyv B 156 B 197
A redox-regulated disulphide may form within Ubiquitin-like modifier-activating enzyme 6 between cysteines 156 and 197. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
7pyv
Structure name
crystal structure of human uba6 in complex with the ubiquitin-like modifier fat10
Structure deposition date
2021-10-11
Thiol separation (Å)
8
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
100
Peptide accession
A0AVT1
Residue number A
156
Residue number B
197
Peptide name
Ubiquitin-like modifier-activating enzyme 6
Ligandability
Cysteine 156 of Ubiquitin-like modifier-activating enzyme 6
Cysteine 197 of Ubiquitin-like modifier-activating enzyme 6
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