ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T cell receptor delta variable 3

Intramolecular
Cysteine 40 and cysteine 111
Cysteine 144 and cysteine 194
A redox-regulated disulphide may form within T cell receptor delta variable 3 between cysteines 40 and 111 (24 and 95 respectively in this structure).

Details

Redox score ?
82
PDB code
7lli
Structure name
stimulatory immune receptor protein complex
Structure deposition date
2021-02-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0JD37
Residue number A
40
Residue number B
111
Peptide name
T cell receptor delta variable 3

Ligandability

Cysteine 40 of T cell receptor delta variable 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 111 of T cell receptor delta variable 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within T cell receptor delta variable 3 between cysteines 144 and 194.

Details

Redox score ?
nan
PDB code
7lli
Structure name
stimulatory immune receptor protein complex
Structure deposition date
2021-02-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
A0JD37
Residue number A
144
Residue number B
194
Peptide name
T cell receptor delta variable 3

Ligandability

Cysteine 144 of T cell receptor delta variable 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 194 of T cell receptor delta variable 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 in protein A could not be asigned to a Uniprot residue.
Cysteine 194 in protein B could not be asigned to a Uniprot residue.
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