ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ATP-dependent DNA helicase

Intramolecular
Cysteine 475 and cysteine 478
Cysteine 453 and cysteine 475
Cysteine 471 and cysteine 475
Cysteine 475 and cysteine 479
Cysteine 453 and cysteine 471
Cysteine 453 and cysteine 478
Cysteine 478 and cysteine 479
Cysteine 471 and cysteine 479
Cysteine 471 and cysteine 478
Cysteine 223 and cysteine 224
More...
Cysteine 453 and cysteine 479
Cysteine 224 and cysteine 270
Cysteine 138 and cysteine 223
A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 475 and 478.

Details

Redox score ?
84
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
5
% buried
82
Peptide accession
A0JN36
Residue number A
475
Residue number B
478
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 475 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 453 and 475.

Details

Redox score ?
81
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
74
Minimum pKa ?
5
% buried
90
Peptide accession
A0JN36
Residue number A
453
Residue number B
475
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 453 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 475 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 471 and 475.

Details

Redox score ?
80
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
77
Minimum pKa ?
6
% buried
nan
Peptide accession
A0JN36
Residue number A
471
Residue number B
475
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 471 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 475 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 475 and 479.

Details

Redox score ?
67
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
6
Half-sphere exposure sum ?
61
Minimum pKa ?
5
% buried
58
Peptide accession
A0JN36
Residue number A
475
Residue number B
479
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 475 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 479 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 453 and 471.

Details

Redox score ?
67
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
14
% buried
nan
Peptide accession
A0JN36
Residue number A
453
Residue number B
471
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 453 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 471 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 453 and 478.

Details

Redox score ?
62
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
14
% buried
84
Peptide accession
A0JN36
Residue number A
453
Residue number B
478
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 453 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 478 and 479. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
51
Peptide accession
A0JN36
Residue number A
478
Residue number B
479
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 478 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 479 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 471 and 479. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
nan
Peptide accession
A0JN36
Residue number A
471
Residue number B
479
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 471 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 479 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 471 and 478. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
23
% buried
nan
Peptide accession
A0JN36
Residue number A
471
Residue number B
478
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 471 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 478 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 223 and 224. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
86
Peptide accession
A0JN36
Residue number A
223
Residue number B
224
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 223 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 224 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 453 and 479. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
60
Peptide accession
A0JN36
Residue number A
453
Residue number B
479
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 453 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 479 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 224 and 270. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
35
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
64
Minimum pKa ?
10
% buried
58
Peptide accession
A0JN36
Residue number A
224
Residue number B
270
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 224 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 270 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATP-dependent DNA helicase between cysteines 138 and 223. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
28
PDB code
7a8r
Structure name
structure of recql from bos taurus
Structure deposition date
2020-08-30
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
12
% buried
90
Peptide accession
A0JN36
Residue number A
138
Residue number B
223
Peptide name
ATP-dependent DNA helicase

Ligandability

Cysteine 138 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 223 of ATP-dependent DNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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