ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Transmembrane protein 120B

Intermolecular
Cysteine 64 and cysteine 8
Cysteine 169 and cysteine 169
A redox-regulated disulphide may form between two units of Transmembrane protein 120B at cysteines 64 and 8.

Details

Redox score ?
65
PDB code
7f73
Structure name
cryo-em structure of human tmem120b
Structure deposition date
2021-06-27
Thiol separation (Å)
6
Half-sphere exposure sum ?
48
Minimum pKa ?
9
% buried
14
Peptide A name
Transmembrane protein 120B
Peptide B name
Transmembrane protein 120B
Peptide A accession
A0PK00
Peptide B accession
A0PK00
Peptide A residue number
64
Peptide B residue number
8

Ligandability

Cysteine 64 of Transmembrane protein 120B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 8 of Transmembrane protein 120B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Transmembrane protein 120B at cysteines 169 and 169. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7f73
Structure name
cryo-em structure of human tmem120b
Structure deposition date
2021-06-27
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
82
Peptide A name
Transmembrane protein 120B
Peptide B name
Transmembrane protein 120B
Peptide A accession
A0PK00
Peptide B accession
A0PK00
Peptide A residue number
169
Peptide B residue number
169

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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