ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Alpha glucosidase 2 alpha neutral subunit

Intramolecular
Cysteine 41 and cysteine 47
Cysteine 655 and cysteine 666
A redox-regulated disulphide may form within Alpha glucosidase 2 alpha neutral subunit between cysteines 41 and 47.

Details

Redox score ?
86
PDB code
7k9o
Structure name
co-crystal structure of alpha glucosidase with compound 3
Structure deposition date
2020-09-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
A1A4T2
Residue number A
41
Residue number B
47
Peptide name
Alpha glucosidase 2 alpha neutral subunit

Ligandability

Cysteine 41 of Alpha glucosidase 2 alpha neutral subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 47 of Alpha glucosidase 2 alpha neutral subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Alpha glucosidase 2 alpha neutral subunit between cysteines 655 and 666.

Details

Redox score ?
78
PDB code
7k9o
Structure name
co-crystal structure of alpha glucosidase with compound 3
Structure deposition date
2020-09-29
Thiol separation (Å)
2
Half-sphere exposure sum ?
97
Minimum pKa ?
nan
% buried
nan
Peptide accession
A1A4T2
Residue number A
655
Residue number B
666
Peptide name
Alpha glucosidase 2 alpha neutral subunit

Ligandability

Cysteine 655 of Alpha glucosidase 2 alpha neutral subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 666 of Alpha glucosidase 2 alpha neutral subunit

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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