ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Neuronal PAS domain protein 4

Intramolecular
Cysteine 149 and cysteine 192
A redox-regulated disulphide may form within Neuronal PAS domain protein 4 between cysteines 149 and 192. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
7xi3
Structure name
crystal structure of the npas4-arnt2 heterodimer in complex with dna
Structure deposition date
2022-04-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
98
Peptide accession
A1L327
Residue number A
149
Residue number B
192
Peptide name
Neuronal PAS domain protein 4

Ligandability

Cysteine 149 of Neuronal PAS domain protein 4

Cysteine 192 of Neuronal PAS domain protein 4

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