ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Anti-(ED-B) scFV

Intramolecular
Cysteine 151 and cysteine 217
Cysteine 22 and cysteine 96
A redox-regulated disulphide may form within Anti-(ED-B) scFV between cysteines 151 and 217 (152 and 218 respectively in this structure).

Details

Redox score ?
81
PDB code
7ah1
Structure name
l19 diabody fragment from immunocytokine l19-il2
Structure deposition date
2020-09-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2KBC1
Residue number A
151
Residue number B
217
Peptide name
Anti-(ED-B) scFV

Ligandability

Cysteine 151 of Anti-(ED-B) scFV

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 217 of Anti-(ED-B) scFV

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Anti-(ED-B) scFV between cysteines 22 and 96.

Details

Redox score ?
80
PDB code
7ah1
Structure name
l19 diabody fragment from immunocytokine l19-il2
Structure deposition date
2020-09-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2KBC1
Residue number A
22
Residue number B
96
Peptide name
Anti-(ED-B) scFV

Ligandability

Cysteine 22 of Anti-(ED-B) scFV

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 96 of Anti-(ED-B) scFV

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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