a tool for identifying drug-targetable redox-active disulphides

Variable region-beta 8.5

Intramolecular

Cysteine 24 and cysteine 92

A redox-regulated disulphide may form within Variable region-beta 8.5 between cysteines 24 and 92 (23 and 92 respectively in this structure).

Details

Redox score ?

82

PDB code

Structure name

crystal structure of the g17e/a52v/s54n/k66e/e80v/l81s/t87s/g96v variant of the murine t cell receptor v beta 8

Structure deposition date

2005-08-16

Thiol separation (Å)

2

Half-sphere exposure sum ?

89

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

24

Residue number B

92

Peptide name

Variable region-beta 8

Ligandability

Cysteine 24 of Variable region-beta 8.5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Variable region-beta 8.5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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