a tool for identifying drug-targetable redox-active disulphides

BRE

Intramolecular

Cysteine 23 and cysteine 88

A redox-regulated disulphide may form within BRE between cysteines 23 and 88.

Details

Redox score ?

79

PDB code

Structure name

altered dimer interface decreases stability in an amyloidogenic kappa1 bence jones protein

Structure deposition date

2007-05-24

Thiol separation (Å)

2

Half-sphere exposure sum ?

90

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

23

Residue number B

88

Peptide name

BRE

Ligandability

Cysteine 23 of BRE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 88 of BRE

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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