a tool for identifying drug-targetable redox-active disulphides

B9-scFv

Intramolecular

Cysteine 41 and cysteine 115

A redox-regulated disulphide may form within B9-scFv between cysteines 41 and 115 (22 and 96 respectively in this structure).

Details

Redox score ?

80

PDB code

Structure name

crystal structure of fv polyglutamine complex

Structure deposition date

2007-02-09

Thiol separation (Å)

2

Half-sphere exposure sum ?

85

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

41

Residue number B

115

Peptide name

B9-scFv

Ligandability

Cysteine 41 of B9-scFv

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 115 of B9-scFv

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: