a tool for identifying drug-targetable redox-active disulphides

Cytotoxic Tcell receptor

Intramolecular

Cysteine 42 and cysteine 110

A redox-regulated disulphide may form within Cytotoxic Tcell receptor between cysteines 42 and 110 (22 and 90 respectively in this structure).

Details

Redox score ?

81

PDB code

Structure name

structure of a high-affinity mutant of the 2c tcr in complex with ld/ql9

Structure deposition date

2007-01-11

Thiol separation (Å)

2

Half-sphere exposure sum ?

86

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

42

Residue number B

110

Peptide name

Cytotoxic Tcell receptor

Ligandability

Cysteine 42 of Cytotoxic Tcell receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Cytotoxic Tcell receptor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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