ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Vh gene product

Intramolecular
Cysteine 40 and cysteine 114
Cysteine 40 and cysteine 40
A redox-regulated disulphide may form within Vh gene product between cysteines 40 and 114 (22 and 92 respectively in this structure).

Details

Redox score ?
80
PDB code
2ajz
Structure name
crystal structure of cocaine catalytic antibody 7a1 fab' in complex with ecgonine methyl ester
Structure deposition date
2005-08-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2NUE8
Residue number A
40
Residue number B
114
Peptide name
Vh gene product

Ligandability

Cysteine 40 of Vh gene product

Cysteine 114 of Vh gene product

A redox-regulated disulphide may form within Vh gene product between cysteines 40 and 40 (142 and 208 respectively in this structure).

Details

Redox score ?
78
PDB code
2ajz
Structure name
crystal structure of cocaine catalytic antibody 7a1 fab' in complex with ecgonine methyl ester
Structure deposition date
2005-08-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2NUE8
Residue number A
40
Residue number B
40
Peptide name
Vh gene product

Ligandability

Cysteine 40 of Vh gene product

Cysteine 40 of Vh gene product

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