ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Lambda-chain (AA -20 to 215)

Intramolecular
Cysteine 41 and cysteine 108
Cysteine 157 and cysteine 216
A redox-regulated disulphide may form within Lambda-chain (AA -20 to 215) between cysteines 41 and 108 (20 and 87 respectively in this structure).

Details

Redox score ?
80
PDB code
5wkz
Structure name
vh1-69 germline antibody predicted from cr6261
Structure deposition date
2017-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
93
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2NUT2
Residue number A
41
Residue number B
108
Peptide name
Lambda-chain (AA -20 to 215)

Ligandability

Cysteine 41 of Lambda-chain (AA -20 to 215)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of Lambda-chain (AA -20 to 215)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Lambda-chain (AA -20 to 215) between cysteines 157 and 216 (137 and 196 respectively in this structure).

Details

Redox score ?
78
PDB code
5wkz
Structure name
vh1-69 germline antibody predicted from cr6261
Structure deposition date
2017-07-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
A2NUT2
Residue number A
157
Residue number B
216
Peptide name
Lambda-chain (AA -20 to 215)

Ligandability

Cysteine 157 of Lambda-chain (AA -20 to 215)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of Lambda-chain (AA -20 to 215)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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