ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IL17RB protein

Intramolecular
Cysteine 254 and cysteine 258
Cysteine 162 and cysteine 173
Cysteine 24 and cysteine 102
Cysteine 187 and cysteine 268
Cysteine 87 and cysteine 99
Cysteine 162 and cysteine 254
A redox-regulated disulphide may form within IL17RB protein between cysteines 254 and 258 (237 and 241 respectively in this structure).

Details

Redox score ?
86
PDB code
7wg3
Structure name
structural basis of interleukin-17b receptor in complex with a neutralizing antibody d9 for guiding humanization and affinity maturation for cancer therapy
Structure deposition date
2021-12-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
A3KN55
Residue number A
254
Residue number B
258
Peptide name
IL17RB protein

Ligandability

Cysteine 254 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IL17RB protein between cysteines 162 and 173 (145 and 156 respectively in this structure).

Details

Redox score ?
85
PDB code
7wg3
Structure name
structural basis of interleukin-17b receptor in complex with a neutralizing antibody d9 for guiding humanization and affinity maturation for cancer therapy
Structure deposition date
2021-12-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
A3KN55
Residue number A
162
Residue number B
173
Peptide name
IL17RB protein

Ligandability

Cysteine 162 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IL17RB protein between cysteines 24 and 102 (7 and 85 respectively in this structure).

Details

Redox score ?
85
PDB code
7wg3
Structure name
structural basis of interleukin-17b receptor in complex with a neutralizing antibody d9 for guiding humanization and affinity maturation for cancer therapy
Structure deposition date
2021-12-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
A3KN55
Residue number A
24
Residue number B
102
Peptide name
IL17RB protein

Ligandability

Cysteine 24 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IL17RB protein between cysteines 187 and 268 (170 and 251 respectively in this structure).

Details

Redox score ?
83
PDB code
7wg3
Structure name
structural basis of interleukin-17b receptor in complex with a neutralizing antibody d9 for guiding humanization and affinity maturation for cancer therapy
Structure deposition date
2021-12-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
A3KN55
Residue number A
187
Residue number B
268
Peptide name
IL17RB protein

Ligandability

Cysteine 187 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IL17RB protein between cysteines 87 and 99 (70 and 82 respectively in this structure).

Details

Redox score ?
82
PDB code
7wg3
Structure name
structural basis of interleukin-17b receptor in complex with a neutralizing antibody d9 for guiding humanization and affinity maturation for cancer therapy
Structure deposition date
2021-12-28
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
A3KN55
Residue number A
87
Residue number B
99
Peptide name
IL17RB protein

Ligandability

Cysteine 87 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 99 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IL17RB protein between cysteines 162 and 254 (145 and 237 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
7wg3
Structure name
structural basis of interleukin-17b receptor in complex with a neutralizing antibody d9 for guiding humanization and affinity maturation for cancer therapy
Structure deposition date
2021-12-28
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
A3KN55
Residue number A
162
Residue number B
254
Peptide name
IL17RB protein

Ligandability

Cysteine 162 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 254 of IL17RB protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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