ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

WD repeat-containing protein 91

Intramolecular
Cysteine 418 and cysteine 503
Cysteine 725 and cysteine 728
A redox-regulated disulphide may form within WD repeat-containing protein 91 between cysteines 418 and 503. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
6vyc
Structure name
crystal structure of wd-repeat domain of human wdr91
Structure deposition date
2020-02-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
A4D1P6
Residue number A
418
Residue number B
503
Peptide name
WD repeat-containing protein 91

Ligandability

Cysteine 418 of WD repeat-containing protein 91

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 503 of WD repeat-containing protein 91

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within WD repeat-containing protein 91 between cysteines 725 and 728 (710 and 713 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
6vyc
Structure name
crystal structure of wd-repeat domain of human wdr91
Structure deposition date
2020-02-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
nan
% buried
nan
Peptide accession
A4D1P6
Residue number A
725
Residue number B
728
Peptide name
WD repeat-containing protein 91

Ligandability

Cysteine 725 of WD repeat-containing protein 91

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 728 of WD repeat-containing protein 91

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: