ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Immunoblobulin G1 Fab heavy chain variable region

Intramolecular
Cysteine 154 and cysteine 210
Cysteine 19 and cysteine 93
A redox-regulated disulphide may form within Immunoblobulin G1 Fab heavy chain variable region between cysteines 154 and 210 (140 and 196 respectively in this structure).

Details

Redox score ?
80
PDB code
2qad
Structure name
structure of tyrosine-sulfated 412d antibody complexed with hiv-1 yu2 gp120 and cd4
Structure deposition date
2007-06-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
A4F255
Residue number A
154
Residue number B
210
Peptide name
Immunoblobulin G1 Fab heavy chain variable region

Ligandability

Cysteine 154 of Immunoblobulin G1 Fab heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Immunoblobulin G1 Fab heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Immunoblobulin G1 Fab heavy chain variable region between cysteines 19 and 93 (22 and 92 respectively in this structure).

Details

Redox score ?
80
PDB code
2qad
Structure name
structure of tyrosine-sulfated 412d antibody complexed with hiv-1 yu2 gp120 and cd4
Structure deposition date
2007-06-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
A4F255
Residue number A
19
Residue number B
93
Peptide name
Immunoblobulin G1 Fab heavy chain variable region

Ligandability

Cysteine 19 of Immunoblobulin G1 Fab heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 93 of Immunoblobulin G1 Fab heavy chain variable region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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