ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Probable crossover junction endonuclease EME2

Intramolecular
Cysteine 102 and cysteine 104
Cysteine 328 and cysteine 363
Cysteine 102 and cysteine 248
Cysteine 104 and cysteine 248
Cysteine 79 and cysteine 104
Cysteine 79 and cysteine 102
A redox-regulated disulphide may form within Probable crossover junction endonuclease EME2 between cysteines 102 and 104.

Details

Redox score ?
69
PDB code
7f6l
Structure name
crystal structure of human mus81-eme2 complex
Structure deposition date
2021-06-25
Thiol separation (Å)
5
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
44
Peptide accession
A4GXA9
Residue number A
102
Residue number B
104
Peptide name
Probable crossover junction endonuclease EME2

Ligandability

Cysteine 102 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable crossover junction endonuclease EME2 between cysteines 328 and 363. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
55
PDB code
7f6l
Structure name
crystal structure of human mus81-eme2 complex
Structure deposition date
2021-06-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
10
% buried
22
Peptide accession
A4GXA9
Residue number A
328
Residue number B
363
Peptide name
Probable crossover junction endonuclease EME2

Ligandability

Cysteine 328 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 363 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable crossover junction endonuclease EME2 between cysteines 102 and 248. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
7f6l
Structure name
crystal structure of human mus81-eme2 complex
Structure deposition date
2021-06-25
Thiol separation (Å)
7
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
60
Peptide accession
A4GXA9
Residue number A
102
Residue number B
248
Peptide name
Probable crossover junction endonuclease EME2

Ligandability

Cysteine 102 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable crossover junction endonuclease EME2 between cysteines 104 and 248. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7f6l
Structure name
crystal structure of human mus81-eme2 complex
Structure deposition date
2021-06-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
48
Peptide accession
A4GXA9
Residue number A
104
Residue number B
248
Peptide name
Probable crossover junction endonuclease EME2

Ligandability

Cysteine 104 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 248 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable crossover junction endonuclease EME2 between cysteines 79 and 104. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
7f6l
Structure name
crystal structure of human mus81-eme2 complex
Structure deposition date
2021-06-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
39
Peptide accession
A4GXA9
Residue number A
79
Residue number B
104
Peptide name
Probable crossover junction endonuclease EME2

Ligandability

Cysteine 79 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Probable crossover junction endonuclease EME2 between cysteines 79 and 102. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
7f6l
Structure name
crystal structure of human mus81-eme2 complex
Structure deposition date
2021-06-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
50
Peptide accession
A4GXA9
Residue number A
79
Residue number B
102
Peptide name
Probable crossover junction endonuclease EME2

Ligandability

Cysteine 79 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 102 of Probable crossover junction endonuclease EME2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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