ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Eukaryotic translation initiation factor 2 alpha kinase 3

Intramolecular
Cysteine 217 and cysteine 222
A redox-regulated disulphide may form within Eukaryotic translation initiation factor 2 alpha kinase 3 between cysteines 217 and 222.

Details

Redox score ?
75
PDB code
5v1d
Structure name
complex structure of the bovine perk luminal domain and its substrate peptide
Structure deposition date
2017-03-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
71
Minimum pKa ?
10
% buried
41
Peptide accession
A5D791
Residue number A
217
Residue number B
222
Peptide name
Eukaryotic translation initiation factor 2 alpha kinase 3

Ligandability

Cysteine 217 of Eukaryotic translation initiation factor 2 alpha kinase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 222 of Eukaryotic translation initiation factor 2 alpha kinase 3

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: