ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Ribonuclease L

Intramolecular
Cysteine 291 and cysteine 299
Cysteine 427 and cysteine 431
A redox-regulated disulphide may form within Ribonuclease L between cysteines 291 and 299. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
6m12
Structure name
crystal structure of rnase l in complex with su11652
Structure deposition date
2020-02-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
60
Minimum pKa ?
10
% buried
48
Peptide accession
A5H025
Residue number A
291
Residue number B
299
Peptide name
Ribonuclease L

Ligandability

Cysteine 291 of Ribonuclease L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 299 of Ribonuclease L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease L between cysteines 427 and 431. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
7elw
Structure name
crystal structure of rnase l in complex with myricetin
Structure deposition date
2021-04-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
11
% buried
100
Peptide accession
A5H025
Residue number A
427
Residue number B
431
Peptide name
Ribonuclease L

Ligandability

Cysteine 427 of Ribonuclease L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 431 of Ribonuclease L

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: