ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Uridine phosphorylase

Intermolecular
Cysteine 224 and cysteine 21
Intramolecular
Cysteine 21 and cysteine 260
Cysteine 257 and cysteine 260
Cysteine 208 and cysteine 268
A redox-regulated disulphide may form between two units of Uridine phosphorylase at cysteines 224 and 21. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
50
PDB code
3ku4
Structure name
trapping of an oxocarbenium ion intermediate in up crystals
Structure deposition date
2009-11-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
11
% buried
98
Peptide A name
Uridine phosphorylase
Peptide B name
Uridine phosphorylase
Peptide A accession
A5PJH9
Peptide B accession
A5PJH9
Peptide A residue number
224
Peptide B residue number
21

Ligandability

Cysteine 224 of Uridine phosphorylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 21 of Uridine phosphorylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Uridine phosphorylase between cysteines 21 and 260.

Details

Redox score ?
69
PDB code
3ku4
Structure name
trapping of an oxocarbenium ion intermediate in up crystals
Structure deposition date
2009-11-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
61
Minimum pKa ?
10
% buried
60
Peptide accession
A5PJH9
Residue number A
21
Residue number B
260
Peptide name
Uridine phosphorylase

Ligandability

Cysteine 21 of Uridine phosphorylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Uridine phosphorylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Uridine phosphorylase between cysteines 257 and 260. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
3ku4
Structure name
trapping of an oxocarbenium ion intermediate in up crystals
Structure deposition date
2009-11-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
72
Minimum pKa ?
13
% buried
92
Peptide accession
A5PJH9
Residue number A
257
Residue number B
260
Peptide name
Uridine phosphorylase

Ligandability

Cysteine 257 of Uridine phosphorylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 260 of Uridine phosphorylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Uridine phosphorylase between cysteines 208 and 268. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
3kvr
Structure name
trapping of an oxocarbenium ion intermediate in up crystals
Structure deposition date
2009-11-30
Thiol separation (Å)
10
Half-sphere exposure sum ?
97
Minimum pKa ?
12
% buried
100
Peptide accession
A5PJH9
Residue number A
208
Residue number B
268
Peptide name
Uridine phosphorylase

Ligandability

Cysteine 208 of Uridine phosphorylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of Uridine phosphorylase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: