DNA-directed RNA polymerase subunit beta
Intramolecular
Cysteine 1119 and cysteine 1137
Cysteine 1119 and cysteine 1122
Cysteine 1119 and cysteine 1140
Cysteine 1122 and cysteine 1140
Cysteine 1137 and cysteine 1140
Cysteine 1122 and cysteine 1137
Cysteine 172 and cysteine 177
Cysteine 510 and cysteine 707
Cysteine 837 and cysteine 892
Cysteine 221 and cysteine 224
More...Cysteine 221 and cysteine 572
Cysteine 26 and cysteine 696
5flm B 1119 B 1137
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1119 and 1137.
Details
Redox score ?
90
PDB code
5flm
Structure name
structure of transcribing mammalian rna polymerase ii
Structure deposition date
2015-10-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
69
Minimum pKa ?
1
% buried
50
Peptide accession
A5PJW8
Residue number A
1119
Residue number B
1137
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1119 of DNA-directed RNA polymerase subunit beta
Cysteine 1137 of DNA-directed RNA polymerase subunit beta
5oik B 1119 B 1122
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1119 and 1122.
Details
Redox score ?
90
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
1
% buried
64
Peptide accession
A5PJW8
Residue number A
1119
Residue number B
1122
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1119 of DNA-directed RNA polymerase subunit beta
Cysteine 1122 of DNA-directed RNA polymerase subunit beta
5oik B 1119 B 1140
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1119 and 1140.
Details
Redox score ?
86
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
1
% buried
48
Peptide accession
A5PJW8
Residue number A
1119
Residue number B
1140
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1119 of DNA-directed RNA polymerase subunit beta
Cysteine 1140 of DNA-directed RNA polymerase subunit beta
5flm B 1122 B 1140
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1122 and 1140.
Details
Redox score ?
76
PDB code
5flm
Structure name
structure of transcribing mammalian rna polymerase ii
Structure deposition date
2015-10-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
61
Minimum pKa ?
8
% buried
51
Peptide accession
A5PJW8
Residue number A
1122
Residue number B
1140
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1122 of DNA-directed RNA polymerase subunit beta
Cysteine 1140 of DNA-directed RNA polymerase subunit beta
5oik B 1137 B 1140
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1137 and 1140.
Details
Redox score ?
74
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
8
% buried
52
Peptide accession
A5PJW8
Residue number A
1137
Residue number B
1140
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1137 of DNA-directed RNA polymerase subunit beta
Cysteine 1140 of DNA-directed RNA polymerase subunit beta
5flm B 1122 B 1137
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 1122 and 1137.
Details
Redox score ?
70
PDB code
5flm
Structure name
structure of transcribing mammalian rna polymerase ii
Structure deposition date
2015-10-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
11
% buried
64
Peptide accession
A5PJW8
Residue number A
1122
Residue number B
1137
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 1122 of DNA-directed RNA polymerase subunit beta
Cysteine 1137 of DNA-directed RNA polymerase subunit beta
5oik B 172 B 177
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 172 and 177. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
8
Half-sphere exposure sum ?
59
Minimum pKa ?
11
% buried
64
Peptide accession
A5PJW8
Residue number A
172
Residue number B
177
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 172 of DNA-directed RNA polymerase subunit beta
Cysteine 177 of DNA-directed RNA polymerase subunit beta
5flm B 510 B 707
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 510 and 707. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
36
PDB code
5flm
Structure name
structure of transcribing mammalian rna polymerase ii
Structure deposition date
2015-10-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
100
Peptide accession
A5PJW8
Residue number A
510
Residue number B
707
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 510 of DNA-directed RNA polymerase subunit beta
Cysteine 707 of DNA-directed RNA polymerase subunit beta
5oik B 837 B 892
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 837 and 892. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
11
% buried
61
Peptide accession
A5PJW8
Residue number A
837
Residue number B
892
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 837 of DNA-directed RNA polymerase subunit beta
Cysteine 892 of DNA-directed RNA polymerase subunit beta
5oik B 221 B 224
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 221 and 224. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
34
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
86
Peptide accession
A5PJW8
Residue number A
221
Residue number B
224
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 221 of DNA-directed RNA polymerase subunit beta
Cysteine 224 of DNA-directed RNA polymerase subunit beta
5oik B 221 B 572
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 221 and 572. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
5oik
Structure name
structure of an rna polymerase ii-dsif transcription elongation complex
Structure deposition date
2017-07-18
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
98
Peptide accession
A5PJW8
Residue number A
221
Residue number B
572
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 221 of DNA-directed RNA polymerase subunit beta
Cysteine 572 of DNA-directed RNA polymerase subunit beta
5flm B 26 B 696
A redox-regulated disulphide may form within DNA-directed RNA polymerase subunit beta between cysteines 26 and 696. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
29
PDB code
5flm
Structure name
structure of transcribing mammalian rna polymerase ii
Structure deposition date
2015-10-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
94
Peptide accession
A5PJW8
Residue number A
26
Residue number B
696
Peptide name
DNA-directed RNA polymerase subunit beta
Ligandability
Cysteine 26 of DNA-directed RNA polymerase subunit beta
Cysteine 696 of DNA-directed RNA polymerase subunit beta
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