ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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CCR4-NOT transcription complex subunit 1

Intramolecular
Cysteine 1457 and cysteine 1504 L
Cysteine 2359 and cysteine 2360 L
Cysteine 1500 and cysteine 1504
Cysteine 1504 and cysteine 1505
Cysteine 1457 and cysteine 1500 L
Cysteine 1902 and cysteine 1906
Cysteine 1906 and cysteine 1932
Cysteine 1457 and cysteine 1505 L
Cysteine 1500 and cysteine 1505
A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 1 between cysteines 1457 and 1504.

Details

Redox score ?
73
PDB code
4ct7
Structure name
cnot9-cnot1 complex with bound tryptophan
Structure deposition date
2014-03-12
Thiol separation (Å)
3
Half-sphere exposure sum ?
87
Minimum pKa ?
8
% buried
100
Peptide accession
A5YKK6
Residue number A
1457
Residue number B
1504
Peptide name
CCR4-NOT transcription complex subunit 1

Ligandability

Cysteine 1457 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 1504 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 1 between cysteines 2359 and 2360.

Details

Redox score ?
70
PDB code
5fu7
Structure name
drosophila nanos nbr peptide bound to the not module of the human ccr4-not complex
Structure deposition date
2016-01-21
Thiol separation (Å)
5
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
49
Peptide accession
A5YKK6
Residue number A
2359
Residue number B
2360
Peptide name
CCR4-NOT transcription complex subunit 1

Ligandability

Cysteine 2359 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 2360 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 1 between cysteines 1500 and 1504. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
4crv
Structure name
complex of human cnot9 and cnot1 including two tryptophans
Structure deposition date
2014-03-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
87
Minimum pKa ?
7
% buried
93
Peptide accession
A5YKK6
Residue number A
1500
Residue number B
1504
Peptide name
CCR4-NOT transcription complex subunit 1

Ligandability

Cysteine 1500 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1504 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 1 between cysteines 1504 and 1505. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
4ct7
Structure name
cnot9-cnot1 complex with bound tryptophan
Structure deposition date
2014-03-12
Thiol separation (Å)
6
Half-sphere exposure sum ?
95
Minimum pKa ?
8
% buried
98
Peptide accession
A5YKK6
Residue number A
1504
Residue number B
1505
Peptide name
CCR4-NOT transcription complex subunit 1

Ligandability

Cysteine 1504 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1505 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 1 between cysteines 1457 and 1500. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5ona
Structure name
drosophila bag-of-marbles cbm peptide bound to human caf40-cnot1
Structure deposition date
2017-08-03
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
12
% buried
91
Peptide accession
A5YKK6
Residue number A
1457
Residue number B
1500
Peptide name
CCR4-NOT transcription complex subunit 1

Ligandability

Cysteine 1457 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 1500 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 1 between cysteines 1902 and 1906. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
5fu6
Structure name
not module of the human ccr4-not complex (crystallization mutant)
Structure deposition date
2016-01-21
Thiol separation (Å)
7
Half-sphere exposure sum ?
79
Minimum pKa ?
13
% buried
100
Peptide accession
A5YKK6
Residue number A
1902
Residue number B
1906
Peptide name
CCR4-NOT transcription complex subunit 1

Ligandability

Cysteine 1902 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1906 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 1 between cysteines 1906 and 1932. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
5fu7
Structure name
drosophila nanos nbr peptide bound to the not module of the human ccr4-not complex
Structure deposition date
2016-01-21
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
96
Peptide accession
A5YKK6
Residue number A
1906
Residue number B
1932
Peptide name
CCR4-NOT transcription complex subunit 1

Ligandability

Cysteine 1906 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1932 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 1 between cysteines 1457 and 1505. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4ct6
Structure name
cnot9-cnot1 complex
Structure deposition date
2014-03-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
84
Minimum pKa ?
14
% buried
98
Peptide accession
A5YKK6
Residue number A
1457
Residue number B
1505
Peptide name
CCR4-NOT transcription complex subunit 1

Ligandability

Cysteine 1457 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

Cysteine 1505 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within CCR4-NOT transcription complex subunit 1 between cysteines 1500 and 1505. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
4ct6
Structure name
cnot9-cnot1 complex
Structure deposition date
2014-03-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
85
Minimum pKa ?
12
% buried
90
Peptide accession
A5YKK6
Residue number A
1500
Residue number B
1505
Peptide name
CCR4-NOT transcription complex subunit 1

Ligandability

Cysteine 1500 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1505 of CCR4-NOT transcription complex subunit 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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