ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IgLON family member 5

Intramolecular
Cysteine 154 and cysteine 195
Cysteine 238 and cysteine 291
Cysteine 54 and cysteine 112
A redox-regulated disulphide may form within IgLON family member 5 between cysteines 154 and 195.

Details

Redox score ?
84
PDB code
6dle
Structure name
crystal structure of iglon5 homodimer
Structure deposition date
2018-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
A6NGN9
Residue number A
154
Residue number B
195
Peptide name
IgLON family member 5

Ligandability

Cysteine 154 of IgLON family member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 195 of IgLON family member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IgLON family member 5 between cysteines 238 and 291.

Details

Redox score ?
81
PDB code
6dle
Structure name
crystal structure of iglon5 homodimer
Structure deposition date
2018-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
A6NGN9
Residue number A
238
Residue number B
291
Peptide name
IgLON family member 5

Ligandability

Cysteine 238 of IgLON family member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 291 of IgLON family member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IgLON family member 5 between cysteines 54 and 112.

Details

Redox score ?
78
PDB code
6dld
Structure name
crystal structure of iglon5/negr1 heterodimer
Structure deposition date
2018-06-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
A6NGN9
Residue number A
54
Residue number B
112
Peptide name
IgLON family member 5

Ligandability

Cysteine 54 of IgLON family member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 112 of IgLON family member 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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