ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Fructose-bisphosphate aldolase

Intramolecular
Cysteine 135 and cysteine 178
Cysteine 73 and cysteine 339
A redox-regulated disulphide may form within Fructose-bisphosphate aldolase between cysteines 135 and 178.

Details

Redox score ?
71
PDB code
7u5j
Structure name
cryo-em structure of aldoa
Structure deposition date
2022-03-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
8
% buried
97
Peptide accession
A6QLL8
Residue number A
135
Residue number B
178
Peptide name
Fructose-bisphosphate aldolase

Ligandability

Cysteine 135 of Fructose-bisphosphate aldolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 178 of Fructose-bisphosphate aldolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fructose-bisphosphate aldolase between cysteines 73 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
7u5j
Structure name
cryo-em structure of aldoa
Structure deposition date
2022-03-02
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
10
% buried
68
Peptide accession
A6QLL8
Residue number A
73
Residue number B
339
Peptide name
Fructose-bisphosphate aldolase

Ligandability

Cysteine 73 of Fructose-bisphosphate aldolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of Fructose-bisphosphate aldolase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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