ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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DAP3 protein

Intramolecular
Cysteine 382 and cysteine 421
A redox-regulated disulphide may form within DAP3 protein between cysteines 382 and 421 (355 and 394 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
6neq
Structure name
structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit-class-ii
Structure deposition date
2018-12-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
12
% buried
100
Peptide accession
A6QQP1
Residue number A
382
Residue number B
421
Peptide name
DAP3 protein

Ligandability

Cysteine 382 of DAP3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 421 of DAP3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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