a tool for identifying drug-targetable redox-active disulphides

Dipeptidyl-peptidase 6

Intermolecular

Cysteine 236 of Potassium voltage-gated channel subfamily D member 2 and cysteine 43

A redox-regulated disulphide may form between cysteine 236 of Potassium voltage-gated channel subfamily D member 2 and cysteine 43 of Dipeptidyl-peptidase 6 (236 and 107 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

44

PDB code

Structure name

human kv4

Structure deposition date

2022-04-01

Thiol separation (Å)

9

Half-sphere exposure sum ?

57

Minimum pK_a ?

10

% buried

51

Peptide A name

Potassium voltage-gated channel subfamily D member 2

Peptide B name

Dipeptidyl-peptidase 6

Peptide A accession

Peptide B accession

Peptide A residue number

236

Peptide B residue number

43

Ligandability

Cysteine 236 of Potassium voltage-gated channel subfamily D member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 43 of Dipeptidyl-peptidase 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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