a tool for identifying drug-targetable redox-active disulphides

Rho GTPase-activating protein 32

Intramolecular

Cysteine 392 and cysteine 446

A redox-regulated disulphide may form within Rho GTPase-activating protein 32 between cysteines 392 and 446.

Details

Redox score ?

62

PDB code

Structure name

crystal structure of the rhogap domain of rics

Structure deposition date

2009-08-31

Thiol separation (Å)

5

Half-sphere exposure sum ?

83

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

392

Residue number B

446

Peptide name

Rho GTPase-activating protein 32

Ligandability

Cysteine 392 of Rho GTPase-activating protein 32

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 446 of Rho GTPase-activating protein 32

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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