a tool for identifying drug-targetable redox-active disulphides

RNA helicase

Intramolecular

Cysteine 564 and cysteine 599

A redox-regulated disulphide may form within RNA helicase between cysteines 564 and 599.

Details

Redox score ?

76

PDB code

Structure name

melanoma differentiation associated protein-5 helicase domain complex with inhibitor non-structural protein v

Structure deposition date

2012-11-21

Thiol separation (Å)

4

Half-sphere exposure sum ?

60

Minimum pK_a ?

8

% buried

62

Peptide accession

Residue number A

564

Residue number B

599

Peptide name

RNA helicase

Ligandability

Cysteine 564 of RNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 599 of RNA helicase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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