a tool for identifying drug-targetable redox-active disulphides

BSLF2/BMLF1 protein

Intermolecular

Cysteine 188 of MHC class I antigen and cysteine 302

A redox-regulated disulphide may form between cysteine 188 of MHC class I antigen and cysteine 302 of BSLF2/BMLF1 protein (164 and 3 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

38

PDB code

Structure name

genetic and structural basis for selection of a ubiquitous t cell receptor deployed in epstein-barr virus

Structure deposition date

2010-07-27

Thiol separation (Å)

9

Half-sphere exposure sum ?

87

Minimum pK_a ?

11

% buried

nan

Peptide A name

MHC class I antigen

Peptide B name

BSLF2/BMLF1 protein

Peptide A accession

Peptide B accession

Peptide A residue number

188

Peptide B residue number

302

Ligandability

Cysteine 188 of MHC class I antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 302 of BSLF2/BMLF1 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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