ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ceramidase

Intermolecular
Cysteine 31 and cysteine 340
Intramolecular
Cysteine 388 and cysteine 392
A redox-regulated disulphide may form between two units of ceramidase at cysteines 31 and 340.

Details

Redox score ?
84
PDB code
5u7z
Structure name
human acid ceramidase (asah1, acdase) self-activated
Structure deposition date
2016-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide A name
ceramidase
Peptide B name
ceramidase
Peptide A accession
A8K0B6
Peptide B accession
A8K0B6
Peptide A residue number
31
Peptide B residue number
340

Ligandability

Cysteine 31 of ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 340 of ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ceramidase between cysteines 388 and 392.

Details

Redox score ?
86
PDB code
5u7z
Structure name
human acid ceramidase (asah1, acdase) self-activated
Structure deposition date
2016-12-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
A8K0B6
Residue number A
388
Residue number B
392
Peptide name
ceramidase

Ligandability

Cysteine 388 of ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 392 of ceramidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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