ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class II antigen

Intramolecular
Cysteine 146 and cysteine 202
Cysteine 44 and cysteine 108
A redox-regulated disulphide may form within MHC class II antigen between cysteines 146 and 202 (117 and 173 respectively in this structure).

Details

Redox score ?
80
PDB code
4c56
Structure name
x-ray structure of the complex between staphylococcal enterotoxin b, t cell receptor and major histocompatibility complex class ii
Structure deposition date
2013-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
A9JJF6
Residue number A
146
Residue number B
202
Peptide name
MHC class II antigen

Ligandability

Cysteine 146 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class II antigen between cysteines 44 and 108 (15 and 79 respectively in this structure).

Details

Redox score ?
79
PDB code
4c56
Structure name
x-ray structure of the complex between staphylococcal enterotoxin b, t cell receptor and major histocompatibility complex class ii
Structure deposition date
2013-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
A9JJF6
Residue number A
44
Residue number B
108
Peptide name
MHC class II antigen

Ligandability

Cysteine 44 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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