ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Intramolecular
Cysteine 151 and cysteine 154
Cysteine 97 and cysteine 151
Cysteine 97 and cysteine 154
A redox-regulated disulphide may form within ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a between cysteines 151 and 154. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6vqg
Structure name
mammalian v-atpase from rat brain membrane-embedded vo region rotational state 2 (from focused refinement)
Structure deposition date
2020-02-05
Thiol separation (Å)
7
Half-sphere exposure sum ?
109
Minimum pKa ?
12
% buried
100
Peptide accession
B0K022
Residue number A
151
Residue number B
154
Peptide name
ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Ligandability

Cysteine 151 of ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a between cysteines 97 and 151. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6vqg
Structure name
mammalian v-atpase from rat brain membrane-embedded vo region rotational state 2 (from focused refinement)
Structure deposition date
2020-02-05
Thiol separation (Å)
8
Half-sphere exposure sum ?
106
Minimum pKa ?
12
% buried
100
Peptide accession
B0K022
Residue number A
97
Residue number B
151
Peptide name
ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Ligandability

Cysteine 97 of ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a between cysteines 97 and 154. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
23
PDB code
6vqh
Structure name
mammalian v-atpase from rat brain membrane-embedded vo region rotational state 3 (from focused refinement)
Structure deposition date
2020-02-05
Thiol separation (Å)
10
Half-sphere exposure sum ?
102
Minimum pKa ?
12
% buried
100
Peptide accession
B0K022
Residue number A
97
Residue number B
154
Peptide name
ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Ligandability

Cysteine 97 of ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of ATPase, H+ transporting, V0 subunit B (Predicted), isoform CRA_a

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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