ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Tripartite motif-containing protein 5

Intramolecular
Cysteine 355 and cysteine 70
Cysteine 365 and cysteine 418
A redox-regulated disulphide may form within Tripartite motif-containing protein 5 between cysteines 355 and 70 (52 and 70 respectively in this structure).

Details

Redox score ?
80
PDB code
4dge
Structure name
trimcyp cyclophilin domain from macaca mulatta: h70c mutant, hiv-1 ca(o-loop) complex
Structure deposition date
2012-01-25
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
B0LJC8
Residue number A
355
Residue number B
70
Peptide name
Tripartite motif-containing protein 5

Ligandability

Cysteine 355 of Tripartite motif-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 of Tripartite motif-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 70 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Tripartite motif-containing protein 5 between cysteines 365 and 418 (62 and 115 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
4dga
Structure name
trimcyp cyclophilin domain from macaca mulatta: hiv-1 ca(o-loop) complex
Structure deposition date
2012-01-25
Thiol separation (Å)
10
Half-sphere exposure sum ?
88
Minimum pKa ?
12
% buried
92
Peptide accession
B0LJC8
Residue number A
365
Residue number B
418
Peptide name
Tripartite motif-containing protein 5

Ligandability

Cysteine 365 of Tripartite motif-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 418 of Tripartite motif-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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