a tool for identifying drug-targetable redox-active disulphides

Tripartite motif-containing protein 5

Intramolecular

Cysteine 364 and cysteine 417

A redox-regulated disulphide may form within Tripartite motif-containing protein 5 between cysteines 364 and 417 (62 and 115 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

28

PDB code

Structure name

evolutionary basis of hiv restriction by the antiretroviral trimcyp

Structure deposition date

2010-03-05

Thiol separation (Å)

10

Half-sphere exposure sum ?

87

Minimum pK_a ?

11

% buried

91

Peptide accession

Residue number A

364

Residue number B

417

Peptide name

Tripartite motif-containing protein 5

Ligandability

Cysteine 364 of Tripartite motif-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 417 of Tripartite motif-containing protein 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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