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NALCN channel auxiliary factor 1

Intramolecular
Cysteine 191 and cysteine 261
Cysteine 255 and cysteine 273
Cysteine 235 and cysteine 322
Cysteine 330 and cysteine 376
Cysteine 313 and cysteine 350
Cysteine 343 and cysteine 370
Cysteine 324 and cysteine 377
Cysteine 255 and cysteine 270
Cysteine 333 and cysteine 385
Cysteine 191 and cysteine 264
More...
Cysteine 261 and cysteine 264
Cysteine 200 and cysteine 255
Cysteine 324 and cysteine 330
Cysteine 376 and cysteine 377
Cysteine 339 and cysteine 386
Cysteine 309 and cysteine 313
Cysteine 322 and cysteine 385
Cysteine 322 and cysteine 339
Cysteine 304 and cysteine 361
Cysteine 341 and cysteine 361
A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 191 and 261.

Details

Redox score ?
91
PDB code
7sx4
Structure name
human nalcn-fam155a-unc79-unc80 channelosome with cam bound, conformation 2/2
Structure deposition date
2021-11-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
B1AL88
Residue number A
191
Residue number B
261
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 191 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 255 and 273.

Details

Redox score ?
85
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
255
Residue number B
273
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 255 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 235 and 322.

Details

Redox score ?
83
PDB code
7cu3
Structure name
structure of mammalian nalcn-fam155a complex at 2
Structure deposition date
2020-08-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
235
Residue number B
322
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 235 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 330 and 376.

Details

Redox score ?
82
PDB code
7wji
Structure name
architecture of the human nalcn channelosome
Structure deposition date
2022-01-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
72
Minimum pKa ?
7
% buried
56
Peptide accession
B1AL88
Residue number A
330
Residue number B
376
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 330 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 376 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 313 and 350.

Details

Redox score ?
80
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
313
Residue number B
350
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 313 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 350 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 343 and 370.

Details

Redox score ?
80
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
343
Residue number B
370
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 343 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 370 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 324 and 377.

Details

Redox score ?
65
PDB code
7wji
Structure name
architecture of the human nalcn channelosome
Structure deposition date
2022-01-06
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
10
% buried
40
Peptide accession
B1AL88
Residue number A
324
Residue number B
377
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 324 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 377 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 255 and 270.

Details

Redox score ?
62
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
255
Residue number B
270
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 255 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 270 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 333 and 385. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
7
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
333
Residue number B
385
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 333 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 191 and 264. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7sx4
Structure name
human nalcn-fam155a-unc79-unc80 channelosome with cam bound, conformation 2/2
Structure deposition date
2021-11-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
nan
Peptide accession
B1AL88
Residue number A
191
Residue number B
264
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 191 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 264 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 261 and 264. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
54
PDB code
7sx3
Structure name
human nalcn-fam155a-unc79-unc80 channelosome with cam bound, conformation 1/2
Structure deposition date
2021-11-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
40
Minimum pKa ?
9
% buried
nan
Peptide accession
B1AL88
Residue number A
261
Residue number B
264
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 261 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 264 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 200 and 255. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
7cu3
Structure name
structure of mammalian nalcn-fam155a complex at 2
Structure deposition date
2020-08-20
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
200
Residue number B
255
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 200 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 324 and 330. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
52
PDB code
6xiw
Structure name
cryo-em structure of the sodium leak channel nalcn-fam155a complex
Structure deposition date
2020-06-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
B1AL88
Residue number A
324
Residue number B
330
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 324 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 330 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 376 and 377. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
7wji
Structure name
architecture of the human nalcn channelosome
Structure deposition date
2022-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
50
Peptide accession
B1AL88
Residue number A
376
Residue number B
377
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 376 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 377 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 339 and 386. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
339
Residue number B
386
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 339 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 386 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 309 and 313. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
nan
Peptide accession
Q8CCS2
Residue number A
309
Residue number B
313
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 309 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 313 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 322 and 385. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
7w7g
Structure name
structure of mammalian nalcn-fam155a-unc79-unc80 quanternary complex
Structure deposition date
2021-12-04
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
322
Residue number B
385
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 322 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 385 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 322 and 339. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
7cu3
Structure name
structure of mammalian nalcn-fam155a complex at 2
Structure deposition date
2020-08-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q8CCS2
Residue number A
322
Residue number B
339
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 322 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 339 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 304 and 361. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
7wji
Structure name
architecture of the human nalcn channelosome
Structure deposition date
2022-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
8
% buried
100
Peptide accession
B1AL88
Residue number A
304
Residue number B
361
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 304 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within NALCN channel auxiliary factor 1 between cysteines 341 and 361. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
7wji
Structure name
architecture of the human nalcn channelosome
Structure deposition date
2022-01-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
14
% buried
100
Peptide accession
B1AL88
Residue number A
341
Residue number B
361
Peptide name
NALCN channel auxiliary factor 1

Ligandability

Cysteine 341 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 361 of NALCN channel auxiliary factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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