ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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ATP-sensitive inward rectifier potassium channel 11

Intramolecular
Cysteine 110 and cysteine 142
A redox-regulated disulphide may form within ATP-sensitive inward rectifier potassium channel 11 between cysteines 110 and 142.

Details

Redox score ?
77
PDB code
7s5y
Structure name
human katp channel in open conformation, focused on kir and one sur, position 2
Structure deposition date
2021-09-12
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
8
% buried
26
Peptide accession
B2RC52
Residue number A
110
Residue number B
142
Peptide name
ATP-sensitive inward rectifier potassium channel 11

Ligandability

Cysteine 110 of ATP-sensitive inward rectifier potassium channel 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 142 of ATP-sensitive inward rectifier potassium channel 11

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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