ATP-binding cassette, sub-family A (ABC1), member 1
Intramolecular
Cysteine 1463 and cysteine 1477
Cysteine 626 and cysteine 1465
Cysteine 1418 and cysteine 1429
Cysteine 355 and cysteine 504
Cysteine 54 and cysteine 81
Cysteine 75 and cysteine 309
Cysteine 1941 and cysteine 2111
Cysteine 1110 and cysteine 1111
Cysteine 1463 and cysteine 1465
Cysteine 2107 and cysteine 2111
More...Cysteine 1465 and cysteine 1477
Cysteine 626 and cysteine 1463
Cysteine 1359 and cysteine 1723
Cysteine 1941 and cysteine 2107
Cysteine 54 and cysteine 626
Cysteine 626 and cysteine 1477
7tbz A 1463 A 1477
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 1463 and 1477.
Details
Redox score ?
88
PDB code
7tbz
Structure name
the structure of abca1 y482c
Structure deposition date
2021-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
1463
Residue number B
1477
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 1463 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 1477 of ATP-binding cassette, sub-family A (ABC1), member 1
7tbw A 626 A 1465
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 626 and 1465.
Details
Redox score ?
86
PDB code
7tbw
Structure name
the structure of atp-bound abca1
Structure deposition date
2021-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
626
Residue number B
1465
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 626 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 1465 of ATP-binding cassette, sub-family A (ABC1), member 1
7tc0 A 1418 A 1429
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 1418 and 1429.
Details
Redox score ?
85
PDB code
7tc0
Structure name
the structure of human abca1 in digitonin
Structure deposition date
2021-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
1418
Residue number B
1429
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 1418 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 1429 of ATP-binding cassette, sub-family A (ABC1), member 1
7tc0 A 355 A 504
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 355 and 504.
Details
Redox score ?
85
PDB code
7tc0
Structure name
the structure of human abca1 in digitonin
Structure deposition date
2021-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
355
Residue number B
504
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 355 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 504 of ATP-binding cassette, sub-family A (ABC1), member 1
7tc0 A 54 A 81
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 54 and 81.
Details
Redox score ?
84
PDB code
7tc0
Structure name
the structure of human abca1 in digitonin
Structure deposition date
2021-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
54
Residue number B
81
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 54 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 81 of ATP-binding cassette, sub-family A (ABC1), member 1
7tbw A 75 A 309
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 75 and 309.
Details
Redox score ?
81
PDB code
7tbw
Structure name
the structure of atp-bound abca1
Structure deposition date
2021-12-22
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
75
Residue number B
309
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 75 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 309 of ATP-binding cassette, sub-family A (ABC1), member 1
7tbw A 1941 A 2111
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 1941 and 2111.
Details
Redox score ?
68
PDB code
7tbw
Structure name
the structure of atp-bound abca1
Structure deposition date
2021-12-22
Thiol separation (Å)
4
Half-sphere exposure sum ?
81
Minimum pKa ?
9
% buried
100
Peptide accession
B2RUU2
Residue number A
1941
Residue number B
2111
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 1941 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 2111 of ATP-binding cassette, sub-family A (ABC1), member 1
7tby A 1110 A 1111
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 1110 and 1111.
Details
Redox score ?
61
PDB code
7tby
Structure name
the structure of human abca1 in nanodisc
Structure deposition date
2021-12-22
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
22
Peptide accession
B2RUU2
Residue number A
1110
Residue number B
1111
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 1110 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 1111 of ATP-binding cassette, sub-family A (ABC1), member 1
7tby A 1463 A 1465
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 1463 and 1465. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
59
PDB code
7tby
Structure name
the structure of human abca1 in nanodisc
Structure deposition date
2021-12-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
52
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
1463
Residue number B
1465
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 1463 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 1465 of ATP-binding cassette, sub-family A (ABC1), member 1
7tbz A 2107 A 2111
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 2107 and 2111. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
54
PDB code
7tbz
Structure name
the structure of abca1 y482c
Structure deposition date
2021-12-22
Thiol separation (Å)
7
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
76
Peptide accession
B2RUU2
Residue number A
2107
Residue number B
2111
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 2107 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 2111 of ATP-binding cassette, sub-family A (ABC1), member 1
7tby A 1465 A 1477
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 1465 and 1477. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
7tby
Structure name
the structure of human abca1 in nanodisc
Structure deposition date
2021-12-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
1465
Residue number B
1477
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 1465 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 1477 of ATP-binding cassette, sub-family A (ABC1), member 1
7tbw A 626 A 1463
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 626 and 1463. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
50
PDB code
7tbw
Structure name
the structure of atp-bound abca1
Structure deposition date
2021-12-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
626
Residue number B
1463
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 626 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 1463 of ATP-binding cassette, sub-family A (ABC1), member 1
7tby A 1359 A 1723
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 1359 and 1723. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
7tby
Structure name
the structure of human abca1 in nanodisc
Structure deposition date
2021-12-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
44
Minimum pKa ?
9
% buried
0
Peptide accession
B2RUU2
Residue number A
1359
Residue number B
1723
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 1359 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 1723 of ATP-binding cassette, sub-family A (ABC1), member 1
7tbw A 1941 A 2107
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 1941 and 2107. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
7tbw
Structure name
the structure of atp-bound abca1
Structure deposition date
2021-12-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
B2RUU2
Residue number A
1941
Residue number B
2107
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 1941 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 2107 of ATP-binding cassette, sub-family A (ABC1), member 1
7tbw A 54 A 626
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 54 and 626. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7tbw
Structure name
the structure of atp-bound abca1
Structure deposition date
2021-12-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
54
Residue number B
626
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 54 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 626 of ATP-binding cassette, sub-family A (ABC1), member 1
7tbw A 626 A 1477
A redox-regulated disulphide may form within ATP-binding cassette, sub-family A (ABC1), member 1 between cysteines 626 and 1477. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
7tbw
Structure name
the structure of atp-bound abca1
Structure deposition date
2021-12-22
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
B2RUU2
Residue number A
626
Residue number B
1477
Peptide name
ATP-binding cassette, sub-family A (ABC1), member 1
Ligandability
Cysteine 626 of ATP-binding cassette, sub-family A (ABC1), member 1
Cysteine 1477 of ATP-binding cassette, sub-family A (ABC1), member 1
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