a tool for identifying drug-targetable redox-active disulphides

Mitochondrial transcription termination factor 1

Intramolecular

Cysteine 172 and cysteine 174

A redox-regulated disulphide may form within Mitochondrial transcription termination factor 1 between cysteines 172 and 174 (192 and 194 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

36

PDB code

Structure name

crystal structure of the mterf1 y288a substitution bound to the termination sequence

Structure deposition date

2015-07-18

Thiol separation (Å)

10

Half-sphere exposure sum ?

61

Minimum pK_a ?

10

% buried

60

Peptide accession

Residue number A

172

Residue number B

174

Peptide name

Mitochondrial transcription termination factor 1

Ligandability

Cysteine 172 of Mitochondrial transcription termination factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 174 of Mitochondrial transcription termination factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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