cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Intermolecular
Cysteine 178 and cysteine 178
Intramolecular
Cysteine 141 and cysteine 142
Cysteine 124 and cysteine 142
Cysteine 142 and cysteine 168
Cysteine 141 and cysteine 178
Cysteine 142 and cysteine 178
6h7e A 124 B 124
A redox-regulated disulphide may form between two units of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3 at cysteines 178 and 178 (124 and 124 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
53
PDB code
6h7e
Structure name
gef regulatory domain
Structure deposition date
2018-07-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
80
Minimum pKa ?
10
% buried
96
Peptide A name
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Peptide B name
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Peptide A accession
B7Z5J6
Peptide B accession
B7Z5J6
Peptide A residue number
178
Peptide B residue number
178
Ligandability
6h7e B 87 B 88
A redox-regulated disulphide may form within cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3 between cysteines 141 and 142 (87 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6h7e
Structure name
gef regulatory domain
Structure deposition date
2018-07-31
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
11
% buried
78
Peptide accession
B7Z5J6
Residue number A
141
Residue number B
142
Peptide name
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Ligandability
Cysteine 141 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Cysteine 142 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
6h7e B 70 B 88
A redox-regulated disulphide may form within cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3 between cysteines 124 and 142 (70 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
6h7e
Structure name
gef regulatory domain
Structure deposition date
2018-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
54
Peptide accession
B7Z5J6
Residue number A
124
Residue number B
142
Peptide name
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Ligandability
Cysteine 124 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Cysteine 142 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
6h7e A 88 A 114
A redox-regulated disulphide may form within cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3 between cysteines 142 and 168 (88 and 114 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6h7e
Structure name
gef regulatory domain
Structure deposition date
2018-07-31
Thiol separation (Å)
8
Half-sphere exposure sum ?
89
Minimum pKa ?
12
% buried
100
Peptide accession
B7Z5J6
Residue number A
142
Residue number B
168
Peptide name
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Ligandability
Cysteine 142 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Cysteine 168 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
6h7e A 87 A 124
A redox-regulated disulphide may form within cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3 between cysteines 141 and 178 (87 and 124 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
6h7e
Structure name
gef regulatory domain
Structure deposition date
2018-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
83
Peptide accession
B7Z5J6
Residue number A
141
Residue number B
178
Peptide name
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Ligandability
Cysteine 141 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Cysteine 178 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
6h7e A 88 A 124
A redox-regulated disulphide may form within cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3 between cysteines 142 and 178 (88 and 124 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
28
PDB code
6h7e
Structure name
gef regulatory domain
Structure deposition date
2018-07-31
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
10
% buried
100
Peptide accession
B7Z5J6
Residue number A
142
Residue number B
178
Peptide name
cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Ligandability
Cysteine 142 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
Cysteine 178 of cDNA FLJ56134, highly similar to Rap guanine nucleotide exchange factor 3
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