a tool for identifying drug-targetable redox-active disulphides

P-type Cu(+) transporter

Intramolecular

Cysteine 370 and cysteine 373

A redox-regulated disulphide may form within P-type Cu(+) transporter between cysteines 370 and 373 (14 and 17 respectively in this structure).

Details

Redox score ?

77

PDB code

Structure name

copper transporter protein

Structure deposition date

2018-07-01

Thiol separation (Å)

3

Half-sphere exposure sum ?

39

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

370

Residue number B

373

Peptide name

P-type Cu(+) transporter

Ligandability

Cysteine 370 of P-type Cu(+) transporter

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 373 of P-type Cu(+) transporter

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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