ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Fanconi anemia, complementation group I

Intramolecular
Cysteine 1085 and cysteine 1158
Cysteine 750 and cysteine 777
Cysteine 71 and cysteine 72
Cysteine 670 and cysteine 674
Cysteine 1014 and cysteine 1025
Cysteine 669 and cysteine 674
Cysteine 669 and cysteine 670
Cysteine 1167 and cysteine 1209
A redox-regulated disulphide may form within Fanconi anemia, complementation group I between cysteines 1085 and 1158.

Details

Redox score ?
75
PDB code
6vad
Structure name
fanconi anemia id complex
Structure deposition date
2019-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
70
Minimum pKa ?
9
% buried
49
Peptide accession
B7ZMF2
Residue number A
1085
Residue number B
1158
Peptide name
Fanconi anemia, complementation group I

Ligandability

Cysteine 1085 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1158 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi anemia, complementation group I between cysteines 750 and 777.

Details

Redox score ?
71
PDB code
6vaa
Structure name
structure of the fanconi anemia id complex bound to icl dna
Structure deposition date
2019-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
8
% buried
92
Peptide accession
B7ZMF2
Residue number A
750
Residue number B
777
Peptide name
Fanconi anemia, complementation group I

Ligandability

Cysteine 750 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 777 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi anemia, complementation group I between cysteines 71 and 72.

Details

Redox score ?
70
PDB code
6vad
Structure name
fanconi anemia id complex
Structure deposition date
2019-12-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
66
Minimum pKa ?
7
% buried
71
Peptide accession
B7ZMF2
Residue number A
71
Residue number B
72
Peptide name
Fanconi anemia, complementation group I

Ligandability

Cysteine 71 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 72 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi anemia, complementation group I between cysteines 670 and 674.

Details

Redox score ?
67
PDB code
6vad
Structure name
fanconi anemia id complex
Structure deposition date
2019-12-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
84
Minimum pKa ?
9
% buried
100
Peptide accession
B7ZMF2
Residue number A
670
Residue number B
674
Peptide name
Fanconi anemia, complementation group I

Ligandability

Cysteine 670 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 674 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi anemia, complementation group I between cysteines 1014 and 1025. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
6vaf
Structure name
structure of mono-ubiquitinated fancd2 bound to non-ubiquitinated fanci and to dna
Structure deposition date
2019-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
90
Peptide accession
B7ZMF2
Residue number A
1014
Residue number B
1025
Peptide name
Fanconi anemia, complementation group I

Ligandability

Cysteine 1014 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1025 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi anemia, complementation group I between cysteines 669 and 674. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6vaa
Structure name
structure of the fanconi anemia id complex bound to icl dna
Structure deposition date
2019-12-17
Thiol separation (Å)
9
Half-sphere exposure sum ?
78
Minimum pKa ?
9
% buried
100
Peptide accession
B7ZMF2
Residue number A
669
Residue number B
674
Peptide name
Fanconi anemia, complementation group I

Ligandability

Cysteine 669 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 674 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi anemia, complementation group I between cysteines 669 and 670. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
6vaf
Structure name
structure of mono-ubiquitinated fancd2 bound to non-ubiquitinated fanci and to dna
Structure deposition date
2019-12-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
80
Minimum pKa ?
14
% buried
100
Peptide accession
B7ZMF2
Residue number A
669
Residue number B
670
Peptide name
Fanconi anemia, complementation group I

Ligandability

Cysteine 669 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 670 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Fanconi anemia, complementation group I between cysteines 1167 and 1209. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
6vae
Structure name
mono-ubiquitinated fanconi anemia id complex bound to icl dna
Structure deposition date
2019-12-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
94
Peptide accession
B7ZMF2
Residue number A
1167
Residue number B
1209
Peptide name
Fanconi anemia, complementation group I

Ligandability

Cysteine 1167 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1209 of Fanconi anemia, complementation group I

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: