ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Odz3 protein

Intramolecular
Cysteine 1331 and cysteine 1384
Cysteine 1160 and cysteine 1163
Cysteine 1450 and cysteine 1458
Cysteine 1264 and cysteine 1272
Cysteine 1448 and cysteine 1456
Cysteine 1456 and cysteine 1458
Cysteine 1450 and cysteine 1456
Cysteine 1448 and cysteine 1458
Cysteine 1448 and cysteine 1450
A redox-regulated disulphide may form within Odz3 protein between cysteines 1331 and 1384 (1347 and 1400 respectively in this structure).

Details

Redox score ?
90
PDB code
6fay
Structure name
teneurin3 monomer
Structure deposition date
2017-12-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
B7ZNJ5
Residue number A
1331
Residue number B
1384
Peptide name
Odz3 protein

Ligandability

Cysteine 1331 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1384 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Odz3 protein between cysteines 1160 and 1163 (1169 and 1172 respectively in this structure).

Details

Redox score ?
89
PDB code
6fay
Structure name
teneurin3 monomer
Structure deposition date
2017-12-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
49
Minimum pKa ?
nan
% buried
nan
Peptide accession
B7ZNJ5
Residue number A
1160
Residue number B
1163
Peptide name
Odz3 protein

Ligandability

Cysteine 1160 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1163 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Odz3 protein between cysteines 1450 and 1458 (1466 and 1474 respectively in this structure).

Details

Redox score ?
86
PDB code
6fay
Structure name
teneurin3 monomer
Structure deposition date
2017-12-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
B7ZNJ5
Residue number A
1450
Residue number B
1458
Peptide name
Odz3 protein

Ligandability

Cysteine 1450 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1458 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Odz3 protein between cysteines 1264 and 1272 (1280 and 1288 respectively in this structure).

Details

Redox score ?
86
PDB code
6fay
Structure name
teneurin3 monomer
Structure deposition date
2017-12-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
B7ZNJ5
Residue number A
1264
Residue number B
1272
Peptide name
Odz3 protein

Ligandability

Cysteine 1264 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1272 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Odz3 protein between cysteines 1448 and 1456 (1464 and 1472 respectively in this structure).

Details

Redox score ?
86
PDB code
6fay
Structure name
teneurin3 monomer
Structure deposition date
2017-12-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
43
Minimum pKa ?
nan
% buried
nan
Peptide accession
B7ZNJ5
Residue number A
1448
Residue number B
1456
Peptide name
Odz3 protein

Ligandability

Cysteine 1448 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1456 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Odz3 protein between cysteines 1456 and 1458 (1472 and 1474 respectively in this structure).

Details

Redox score ?
73
PDB code
6fay
Structure name
teneurin3 monomer
Structure deposition date
2017-12-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
B7ZNJ5
Residue number A
1456
Residue number B
1458
Peptide name
Odz3 protein

Ligandability

Cysteine 1456 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1458 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Odz3 protein between cysteines 1450 and 1456 (1466 and 1472 respectively in this structure).

Details

Redox score ?
67
PDB code
6fay
Structure name
teneurin3 monomer
Structure deposition date
2017-12-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
B7ZNJ5
Residue number A
1450
Residue number B
1456
Peptide name
Odz3 protein

Ligandability

Cysteine 1450 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1456 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Odz3 protein between cysteines 1448 and 1458 (1464 and 1474 respectively in this structure).

Details

Redox score ?
64
PDB code
6fay
Structure name
teneurin3 monomer
Structure deposition date
2017-12-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
B7ZNJ5
Residue number A
1448
Residue number B
1458
Peptide name
Odz3 protein

Ligandability

Cysteine 1448 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1458 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Odz3 protein between cysteines 1448 and 1450 (1464 and 1466 respectively in this structure).

Details

Redox score ?
62
PDB code
6fay
Structure name
teneurin3 monomer
Structure deposition date
2017-12-18
Thiol separation (Å)
6
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
B7ZNJ5
Residue number A
1448
Residue number B
1450
Peptide name
Odz3 protein

Ligandability

Cysteine 1448 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1450 of Odz3 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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