ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Genome polyprotein

Intermolecular
Cysteine 100 of Immunoglobulin gamma-1 heavy chain and cysteine 429
Cysteine 100 of Immunoglobulin gamma-1 heavy chain and cysteine 505
A redox-regulated disulphide may form between cysteine 100 of Immunoglobulin gamma-1 heavy chain and cysteine 429 of Genome polyprotein.

Details

Redox score ?
65
PDB code
6bkb
Structure name
structure of hepatitis c virus envelope glycoprotein e2 core from genotype 6a bound to broadly neutralizing antibody ar3a
Structure deposition date
2017-11-08
Thiol separation (Å)
4
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin gamma-1 heavy chain
Peptide B name
Genome polyprotein
Peptide A accession
P0DOX5
Peptide B accession
B9V0E2
Peptide A residue number
100
Peptide B residue number
429

Ligandability

Cysteine 100 of Immunoglobulin gamma-1 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 429 of Genome polyprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form between cysteine 100 of Immunoglobulin gamma-1 heavy chain and cysteine 505 of Genome polyprotein (100 and 503 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
53
PDB code
6bkb
Structure name
structure of hepatitis c virus envelope glycoprotein e2 core from genotype 6a bound to broadly neutralizing antibody ar3a
Structure deposition date
2017-11-08
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide A name
Immunoglobulin gamma-1 heavy chain
Peptide B name
Genome polyprotein
Peptide A accession
P0DOX5
Peptide B accession
B9V0E2
Peptide A residue number
100
Peptide B residue number
505

Ligandability

Cysteine 100 of Immunoglobulin gamma-1 heavy chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 505 of Genome polyprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 100 in protein A could not be asigned to a Uniprot residue.
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