Suppressor of cytokine signaling

Intermolecular

Cysteine 112 of Elongin-C and cysteine 178

A redox-regulated disulphide may form between cysteine 112 of Elongin-C and cysteine 178 of Suppressor of cytokine signaling. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

6c5x

Structure name

crystal structure of socs1 in complex with elonginb and elonginc

Structure deposition date

2018-01-17

Thiol separation (Å)

Half-sphere exposure sum ?

nan

Minimum pK_a ?

% buried

Peptide A name

Elongin-C

Peptide B name

Suppressor of cytokine signaling

Peptide A accession

Q15369

Peptide B accession

C0LEJ4

Peptide A residue number

112

Peptide B residue number

178

Ligandability

Cysteine 112 of Elongin-C

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.