ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA-B*3507

Intramolecular
Cysteine 125 and cysteine 188
Cysteine 227 and cysteine 283
A redox-regulated disulphide may form within HLA-B*3507 between cysteines 125 and 188 (101 and 164 respectively in this structure).

Details

Redox score ?
81
PDB code
4pri
Structure name
crystal structure of tk3 tcr-hla-b*35:08-hpvg complex
Structure deposition date
2014-03-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
C5MK56
Residue number A
125
Residue number B
188
Peptide name
HLA-B*3507

Ligandability

Cysteine 125 of HLA-B*3507

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 188 of HLA-B*3507

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA-B*3507 between cysteines 227 and 283 (203 and 259 respectively in this structure).

Details

Redox score ?
76
PDB code
4prp
Structure name
crystal structure of tk3 tcr-hla-b*35:01-hpvg-q5 complex
Structure deposition date
2014-03-06
Thiol separation (Å)
3
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
80
Peptide accession
C5MK56
Residue number A
227
Residue number B
283
Peptide name
HLA-B*3507

Ligandability

Cysteine 227 of HLA-B*3507

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 283 of HLA-B*3507

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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