ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class II antigen

Intramolecular
Cysteine 112 and cysteine 168
Cysteine 10 and cysteine 74
A redox-regulated disulphide may form within MHC class II antigen between cysteines 112 and 168 (117 and 173 respectively in this structure).

Details

Redox score ?
80
PDB code
4h1l
Structure name
tcr interaction with peptide mimics of nickel offers structural insights in nickel contact allergy
Structure deposition date
2012-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
D0AB36
Residue number A
112
Residue number B
168
Peptide name
MHC class II antigen

Ligandability

Cysteine 112 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 168 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class II antigen between cysteines 10 and 74 (15 and 79 respectively in this structure).

Details

Redox score ?
79
PDB code
4h1l
Structure name
tcr interaction with peptide mimics of nickel offers structural insights in nickel contact allergy
Structure deposition date
2012-09-10
Thiol separation (Å)
2
Half-sphere exposure sum ?
86
Minimum pKa ?
nan
% buried
nan
Peptide accession
D0AB36
Residue number A
10
Residue number B
74
Peptide name
MHC class II antigen

Ligandability

Cysteine 10 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 74 of MHC class II antigen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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