ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Killer cell lectin-like receptor subfamily F member 2

Intramolecular
Cysteine 78 and cysteine 89
Cysteine 106 and cysteine 193
Cysteine 172 and cysteine 185
A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily F member 2 between cysteines 78 and 89.

Details

Redox score ?
86
PDB code
4iop
Structure name
crystal structure of nkp65 bound to its ligand kacl
Structure deposition date
2013-01-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
51
Minimum pKa ?
nan
% buried
nan
Peptide accession
D3W0D1
Residue number A
78
Residue number B
89
Peptide name
Killer cell lectin-like receptor subfamily F member 2

Ligandability

Cysteine 78 of Killer cell lectin-like receptor subfamily F member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 89 of Killer cell lectin-like receptor subfamily F member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily F member 2 between cysteines 106 and 193.

Details

Redox score ?
83
PDB code
4iop
Structure name
crystal structure of nkp65 bound to its ligand kacl
Structure deposition date
2013-01-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
D3W0D1
Residue number A
106
Residue number B
193
Peptide name
Killer cell lectin-like receptor subfamily F member 2

Ligandability

Cysteine 106 of Killer cell lectin-like receptor subfamily F member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 193 of Killer cell lectin-like receptor subfamily F member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Killer cell lectin-like receptor subfamily F member 2 between cysteines 172 and 185.

Details

Redox score ?
82
PDB code
4iop
Structure name
crystal structure of nkp65 bound to its ligand kacl
Structure deposition date
2013-01-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
D3W0D1
Residue number A
172
Residue number B
185
Peptide name
Killer cell lectin-like receptor subfamily F member 2

Ligandability

Cysteine 172 of Killer cell lectin-like receptor subfamily F member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 185 of Killer cell lectin-like receptor subfamily F member 2

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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