Interleukin-4
Intermolecular
Cysteine 151 and cysteine 231 of Cytokine receptor common subunit gamma
Cysteine 27 and cysteine 231 of Cytokine receptor common subunit gamma
Cysteine 151 and cysteine 182 of Cytokine receptor common subunit gamma
Cysteine 27 and cysteine 182 of Cytokine receptor common subunit gamma
Intramolecular
Cysteine 27 and cysteine 151
Cysteine 70 and cysteine 123
Cysteine 48 and cysteine 89
3qb7 A 127 C 209
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 231 of Cytokine receptor common subunit gamma (127 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
D4HNR6
Peptide B accession
P31785
Peptide A residue number
151
Peptide B residue number
231
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 231 of Cytokine receptor common subunit gamma
3qb7 B 3 D 209
A redox-regulated disulphide may form between cysteine 27 of Interleukin-4 and cysteine 231 of Cytokine receptor common subunit gamma (3 and 209 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
D4HNR6
Peptide B accession
P31785
Peptide A residue number
27
Peptide B residue number
231
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 231 of Cytokine receptor common subunit gamma
3qb7 A 127 C 160
A redox-regulated disulphide may form between cysteine 151 of Interleukin-4 and cysteine 182 of Cytokine receptor common subunit gamma (127 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
D4HNR6
Peptide B accession
P31785
Peptide A residue number
151
Peptide B residue number
182
Ligandability
Cysteine 151 of Interleukin-4
Cysteine 182 of Cytokine receptor common subunit gamma
3qb7 B 3 D 160
A redox-regulated disulphide may form between cysteine 27 of Interleukin-4 and cysteine 182 of Cytokine receptor common subunit gamma (3 and 160 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
42
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
10
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide A name
Interleukin-4
Peptide B name
Cytokine receptor common subunit gamma
Peptide A accession
D4HNR6
Peptide B accession
P31785
Peptide A residue number
27
Peptide B residue number
182
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 182 of Cytokine receptor common subunit gamma
3qb7 B 3 B 127
A redox-regulated disulphide may form within Interleukin-4 between cysteines 27 and 151 (3 and 127 respectively in this structure).
Details
Redox score ?
94
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
D4HNR6
Residue number A
27
Residue number B
151
Peptide name
Interleukin-4
Ligandability
Cysteine 27 of Interleukin-4
Cysteine 151 of Interleukin-4
3qb7 B 46 B 99
A redox-regulated disulphide may form within Interleukin-4 between cysteines 70 and 123 (46 and 99 respectively in this structure).
Details
Redox score ?
86
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
54
Minimum pKa ?
nan
% buried
nan
Peptide accession
D4HNR6
Residue number A
70
Residue number B
123
Peptide name
Interleukin-4
Ligandability
Cysteine 70 of Interleukin-4
Cysteine 123 of Interleukin-4
3qb7 A 24 A 65
A redox-regulated disulphide may form within Interleukin-4 between cysteines 48 and 89 (24 and 65 respectively in this structure).
Details
Redox score ?
84
PDB code
3qb7
Structure name
interleukin-4 mutant rga bound to cytokine receptor common gamma
Structure deposition date
2011-01-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
D4HNR6
Residue number A
48
Residue number B
89
Peptide name
Interleukin-4
Ligandability
Cysteine 48 of Interleukin-4
Cysteine 89 of Interleukin-4
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